Institute of Molecular Biology
The IMB has state-of-the-art equipment, facilities, and service centers.
Genomics and Cell Characterization Facility
The Genomics and Cell Characterization Facility supports scientific research at the University of Oregon by offering genetic, genomic, and cell-analysis technologies. They provide next generation Illumina-based high throughput DNA sequencing and associated bioinformatics, robotics for high throughput manipulation of DNA samples, microarray-based genotyping, microarray printing, a flow cytometer and a high-speed fluorescence activated cell sorter. In addition to equipment, they provide trained operators and expert bioinformatics staff for experimental design, implementation, and interpretation.
The IMB has access to state-of-the-art computing. In additional to individual lab workstations, servers, and clusters, the University of Oregon also maintains a supercomputer
that all IMB members may use. The University and Institute also have staff available for bioinformatics
, and programming
The University of Oregon is the birthplace of the zebrafish as a model system for developmental biology. The University of Oregon maintains a world class, fully staffed zebrafish facility. The facility houses zebrafish, stickleback, and a variety of other fish, with a total capacity of ~80,000 adult zebrafish. The facility possesses a full-time staff to maintain the fish and assist with experimental work. The facility has recently been entirely renovated and expanded, with improvements including doubled square-footage, additional procedure rooms, and space for new microscopes and microinjection rigs.
Transgenic Mouse Facility
The rodent-care facilities at UO occupy ~20,000 square feet and >5,000 cages housing mice and rats. Since its opening in 2004, the Transgenic Mouse Facility has produced more than thousand of mice, including over 30 new lines and many re-derived lines. Our facility also provides Embryonic Stem Cell gene knockout services and has successfully achieved several knockout lines. The TMF goal is to be able to provide all the services necessary to produce and maintain genetically modified mice. These services range from designing projects to maintaining colonies.
Structural Biology and Biophysics Facilities
A wide variety of facilities are available for structural and biophysical studies. These include modern x-ray crystallography and NMR facilities
, a Biacore surface plasmon resonance spectrometer, instrumentation for analytical ultracentrifugation, circular dichroism, calorimetry, light scattering, and additional facilities for the structural and dynamic characterization of macromolecular assemblies.
Media Room and Fly Food Facilities
Located in the IMB, this centralized support facility was developed to provide assistance to researchers both on-campus and in the local community. They offer 3 main areas of service - Glassware Processing, Media Preparation and Fly Food Preparation. For more details, and a list of additional services, please see their website.
Cell Culture and Preparation Facilities
In addition to our specialized zebrafish and mouse facilities, we also maintain shared culture facilities for shared use by all laboratories. This includes mammalian cell culture facilities, as well as space for bacterial, yeast, and phage growth.
Confocal microscopy resources
We have several different laser scanning confocal microscope systems housed in different laboratories but available for shared use. We also have two spinning disk confocal microscope systems, both equipped with dual lasers for two color imaging. A photo-optics facility includes a 2 photon microscope system that is available for general use.
The Electron Microscopy Facility (housed in CAMCOR
) is well equipped for ultrastructural research. It houses two transmission electron microscopes and one scanning electron microscope, and it includes equipment for sample preparation, cryomicroscopy, and freeze-fracture. A comprehensive course in biological electron microscopy is offered each year. One-on-one assistance is also available.
The IMB maintains an excellent technical support team, which provides maintenance and design capabilities in the areas of computing, instrumentation, and electronics.