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George F. Sprague, Jr

George F. Sprague, Jr

Professor, Biology
Member, IMB

Ph.D., Yale University
B.S., North Carolina State

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Research Interests

George Sprague is no longer active in research but is still active in the Biology Department teaching program.

During his research career he used yeast as a model to investigate basic problems in genetics and cell biology. His primary interests were:
sprague research Localization of Bud4p, a protein required for the axial budding pattern. Bud4p was fused to green fluorescence protein (GFP) and visualized by virtue of the intrinsic fluorescence of GFP. Although the budding pattern of yeast cells changes when they are shifted from glucose rich to glucose limiting conditions, the localization of Bud4p does not change.
sprague research The three yeast cell types and the regulatory proteins encoded by the MAT locus are depicted. These proteins, together with Mcm1, which is encoded elsewhere in the genome, govern expression of three sets of genes: a-specific genes, α-specific genes, and a1·α2-repressed genes. Figure taken from: Sprague GF, PNAS 2005;102:959-960.
sprague research Three MAPK pathways in yeast share common components and also contain pathway-specific factors.

Recent publications

(pulled from pubmed)

Recent publications

(pulled from pubmed)

The regulation of filamentous growth in yeast.
Cullen PJ, Sprague GF Jr
Genetics 2012
Eukaryotes learn how to count: quorum sensing by yeast.
Sprague GF Jr, Winans SC
Genes & development 2006
Three-pronged genomic analysis reveals yeast cell-type regulation circuitry.
Sprague GF Jr
Proceedings of the National Academy of Sciences of the United States of America 2005
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.
Cullen PJ, Sabbagh W Jr, Graham E, Irick MM, van Olden EK, Neal C, Delrow J, Bardwell L, Sprague GF Jr
Genes & development 2004
Yeast signal transduction: regulation and interface with cell biology.
Sprague GF, Cullen PJ, Goehring AS
Advances in experimental medicine and biology 2004
Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p.
Goehring AS, Rivers DM, Sprague GF Jr
Eukaryotic cell 2003
Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast.
Goehring AS, Rivers DM, Sprague GF Jr
Molecular biology of the cell 2003
Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation.
Goehring AS, Mitchell DA, Tong AH, Keniry ME, Boone C, Sprague GF Jr
Molecular biology of the cell 2003
GTPase-activating proteins for Cdc42.
Smith GR, Givan SA, Cullen P, Sprague GF Jr
Eukaryotic cell 2002
The roles of bud-site-selection proteins during haploid invasive growth in yeast.
Cullen PJ, Sprague GF Jr
Molecular biology of the cell 2002