Recent Publications from the von Hippel Laboratory (1994-July 2001)
 
Pietroni P, 2001          [See Related Articles]
Dissection of the atp-driven reaction cycle of the bacteriophage t4 dna replication processivity clamp loading system.  J Mol Biol. 2001 Jun 15;309(4):869-91. [Abstract]
Delagoutte E, 2001          [See Related Articles]
Molecular mechanisms of the functional coupling of the helicase (gp41) and polymerase (gp43) of bacteriophage T4 within the DNA replication fork.  Biochemistry. 2001 Apr 10;40(14):4459-77. [Full text PDF file]
Von Hippel PH, 2001          [See Related Articles]
A general model for nucleic acid helicases and their "coupling" within macromolecular machines. Cell 2001 Jan 26;104(2):177-90. [Abstract]
Van Gilst, 2000          [See Related Articles]
Quantitative dissection of transcriptional control system: N-dependent antitermination complex of phage lambda as regulatory paradigm.  Methods Enzymol. 2000;323:1-31.
Pasman Z, 2000          [See Related Articles]
Regulation of rho-dependent transcription termination by NusG is specific to the escherichia coli elongation complex.   Biochemistry. 2000 May 9;39(18):5573-85. [Full text PDF file]
Latham GJ, 1999           [See Related Articles]
Opening of a monomer-monomer interface of the trimeric bacteriophage T4-coded GP45 sliding clamp is required for clamp loading onto DNA.  Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12448-53.  [Full text PDF file]
Jing DH, 1999           [See Related Articles]
Interactions of Bacteriophage T4-coded primase (gp61) with the T4 Replication Helicase (gp41) and DNA in Primosome formation.  J. Biol. Chem. 1999 Sept. 17; 274 (38):  27287-27298.   [Full text PDF file]
Daube SS, 1999           [See Related Articles]
Interactions of Escherichia coli s70 within the transcription elongation complex.  Proc Natl Acad Sci U S A 1999 Jul 20;96(15):8390-5.  [Full text PDF file]
Wilson KS, 1999           [See Related Articles]
Determinants of the stability of Transcription Elongation Complexes:  Interactions of the Nascent RNA with the DNA Template and the RNA polymerase.  J Mol Biol 1999 Jun 25;289(5):1179-94.    [Abstract]
von Hippel PH, 1998            [See Related Articles]
An integrated model of the transcription complex in elongation, termination, and editing.  Science 1998 Jul 31;281(5377):660-5.   [Full Text PDF file]
Zhu AQ, 1998            [See Related Articles]
Mechanisms of rho-dependent transcript termination.  II.  A quantitative model of rho-dependent transcript release.
Biochemistry 1998 Aug 11;37(32):11215-22.   [Full Text PDF file]
Zhu AQ, 1998           [See Related Articles]
Mechanisms of rho-dependent transcript termination.  I.  Rho loading, template sequence, and kinetic competition with the trp t' terminator.
Biochemistry 1998 Aug 11;37(32):11202-14.   [Full Text PDF file]
Walstrom KM,1998           [See Related Articles]
Effects of reaction conditions on RNA secondary structure and on the helicase activity of Escherichia coli transcription termination factor rho.
J Mol Biol 1998 Jun 19;279(4):713-26.   [Abstract]
Lott WB, 1998           [See Related Articles]
A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate.
Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2): 542-547.  [Full Text PDF file]
Latham GJ, 1997           [See Related Articles]
Structural Analyses of gp45 Sliding Clamp Interactions during Assembly of the Bacteriophage T4 DNA Polymerase Holoenzyme. III. The gp43 dna polymerase binds to the same face of the sliding clamp as the clamp loader.
J Biol Chem. 1997 Dec 12; 272(50): 31685-31692.  [Full Text PDF file]
Latham GJ, 1997           [See Related Articles]
Structural Analyses of gp45 Sliding Clamp Interactions during Assembly of the Bacteriophage T4 DNA Polymerase Holoenzyme. II. The gp44/62 clamp loader interacts with a single defined face of the sliding clamp ring.
J Biol Chem. 1997 Dec 12; 272(50): 31677-31684.  [Full Text PDF file]
Pietroni P, 1997           [See Related Articles]
Structural Analyses of gp45 Sliding Clamp Interactions during Assembly of the Bacteriophage T4 DNA Polymerase Holoenzyme. I. Conformational changes within the gp44/62-gp45-ATP complex during clamp loading.
J Biol Chem. 1997 Dec 12; 272(50): 31666-31676.  [Full Text PDF file]
Van Gilst MR, 1997           [See Related Articles]
Assembly of the N-dependent Antitermination Complex of Phage lambda: NusA and RNA Bind Independently to Different Unfolded Domains of the N Protein.
J Mol Biol. 1997 Nov 28; 274(2): 160-173.   [Full Text PDF File]
Rees WA, 1997           [See Related Articles]
Regulation of the Elongation-Termination Decision at Intrinsic Terminators by Antitermination Protein N of Phage lambda.
J Mol Biol. 1997 Nov 7; 273(4): 797-813.   [Full Text PDF File]
Rippe K, 1997           [See Related Articles]
Transcriptional activation via DNA-looping: visualization of intermediates in the activation pathway of E. coli RNA polymerase x sigma 54 holoenzyme by scanning force microscopy.
J Mol Biol. 1997 Jul 11; 270(2): 125-138.   [Full Text PDF File]
Walstrom KM, 1997           [See Related Articles]
Kinetics of the RNA-DNA helicase activity of Escherichia coli transcription termination factor rho. 2. Processivity, ATP consumption, and RNA binding.
Biochemistry. 1997 Jul 1; 36(26): 7993-8004.
Walstrom KM, 1997           [See Related Articles]
Kinetics of the RNA-DNA helicase activity of Escherichia coli transcription termination factor rho. 1. Characterization and analysis of the reaction.
Biochemistry. 1997 Jul 1; 36(26): 7980-7992.
Pontius BW, 1997           [See Related Articles]
Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism.
Proc Natl Acad Sci U S A 94(6), 2290-2294 (1997)
Van Gilst MR, 1997           [See Related Articles]
Complexes of N antitermination protein of phage lambda with specific and nonspecific RNA target sites on the nascent transcript.
Biochemistry 36(6), 1514-1524 (1997)
Dong F, 1996           [See Related Articles]
A coupled complex of T4 DNA replication helicase (gp41) and polymerase (gp43) can perform rapid and processive DNA strand-displacement synthesis.
Proc Natl Acad Sci U S A 93(25), 14456-14461 (1996) .   [Full Text PDF File]
Young MC, 1996           [See Related Articles]
The kinetic mechanism of formation of the bacteriophage T4 DNA polymerase sliding clamp.
J Mol Biol 264(3), 440-452 (1996)   [Full Text PDF File]
Latham GJ, 1996           [See Related Articles]
Fluorescence monitoring of T4 polymerase holoenzyme accessory protein interactions during loading of the sliding clamp onto the template-primer junction.
J Mol Biol 264(3), 426-439 (1996)   [Full Text PDF file]
Dong F, 1996           [See Related Articles]
The ATP-activated hexameric helicase of bacteriophage T4 (gp41) forms a stable primosome with a single subunit of T4-coded primase (gp61).
J Biol Chem 271(32), 19625-19631 (1996) .   [Full Text PDF File]
von Hippel PH, 1996           [See Related Articles]
Specificity mechanisms in the control of transcription.
Biophys Chem 59(3), 231-246 (1996)
Rees WA, 1996           [See Related Articles]
Bacteriophage lambda N protein alone can induce transcription antitermination in vitro.
Proc Natl Acad Sci U S A 93(1), 342-346 (1996)
Das A, 1996           [See Related Articles]
Components of multiprotein-RNA complex that controls transcription elongation in Escherichia coli phage lambda.
Methods Enzymol 274, 374-402 (1996) (no abstract available)
Rippe K, 1995           [See Related Articles]
Action at a distance: DNA-looping and initiation of transcription.
Trends Biochem Sci 20(12), 500-506 (1995)
Wilson KS, 1995           [See Related Articles]
Transcription termination at intrinsic terminators: the role of the RNA hairpin.

          Proc Natl Acad Sci U S A 92(19), 8793-8797 (1995)
Dong F, 1995           [See Related Articles]
The phage T4-coded DNA replication helicase (gp41) forms a hexamer upon activation by nucleoside triphosphate.
J Biol Chem 270(13), 7462-7473 (1995)
von Hippel PH, 1995           [See Related Articles]
A ring to bind eukaryotic DNA polymerase.
Structure 3(1), 123-124 (1995) (no abstract available)
Van Gilst M, 1995           [See Related Articles]
Structural and thermodynamic characteristics of the binding of the lambda N protein to a RNA hairpin.
Nucleic Acids Symp Ser 33, 145-147 (1995)
Walstrom KM, 1995           [See Related Articles]
Production of RNA strands containing nucleotide analogs in only one section.
Nucleic Acids Symp Ser 33, 126-128 (1995)
von Hippel PH, 1995           [See Related Articles]
RNA interactions in the regulation of transcription.
Nucleic Acids Symp Ser 33, 1-4 (1995)
Reddy MK, 1995           [See Related Articles]
Using macromolecular crowding agents to identify weak interactions within DNA replication complexes.
Methods Enzymol 262, 466-476 (1995) (no abstract available)
Wilson KS, 1994           [See Related Articles]
Stability of Escherichia coli transcription complexes near an intrinsic terminator.
J Mol Biol 244(1), 36-51 (1994)
Daube SS, 1994           [See Related Articles]
Coupling of RNA displacement and intrinsic termination in transcription from synthetic RNA.DNA bubble duplex constructs.
Proc Natl Acad Sci U S A 91(20), 9539-9543 (1994)
Von Hippel PH, 1994           [See Related Articles]
On the processivity of polymerases.
Ann N Y Acad Sci 726, 118-131 (1994) (no abstract available)
Daube SS, 1994           [See Related Articles]
Coupling of RNA displacement and intrinsic termination in transcription from synthetic RNA.DNA bubble duplex constructs.
Proc Natl Acad Sci U S A 91(20), 9539-9543 (1994)
Von Hippel PH, 1994           [See Related Articles]
On the processivity of polymerases.
Ann N Y Acad Sci 726, 118-131 (1994) (no abstract available)
 

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