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Tom H. Stevens

Tom H. Stevens

Professor, Chemistry and Biochemistry
Member, IMB

Ph.D., California Institute of Technology
M.S., San Francisco State University
B.A., San Francisco State University

Email
Office: Streisinger Hall Room 255C
Office Phone: 541-346-5884
Lab: Streisinger Hall Room 255
Lab Phone: 541-346-4608

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Research Interests

Tom Stevens is no longer active in research but is still active in the Chemistry & Biochemistry Department teaching program.

Recent publications

(pulled from pubmed)

Recent publications

(pulled from pubmed)

Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain.
Coonrod EM, Graham LA, Carpp LN, Carr TM, Stirrat L, Bowers K, Bryant NJ, Stevens TH
Dev Cell 2013 Nov 25;27(4):462-8
Evolution of increased complexity in a molecular machine.
Finnigan GC, Hanson-Smith V, Stevens TH, Thornton JW
Nature 2012 Jan 9;481(7381):360-4
Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p.
Finnigan GC, Cronan GE, Park HJ, Srinivasan S, Quiocho FA, Stevens TH
J Biol Chem 2012 Jun 1;287(23):19487-500
A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae.
Finnigan GC, Ryan M, Stevens TH
Genetics 2011 Mar;187(3):771-83
The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae.
Finnigan GC, Hanson-Smith V, Houser BD, Park HJ, Stevens TH
Mol Biol Cell 2011 Sep;22(17):3176-91
The yeast vps class E mutants: the beginning of the molecular genetic analysis of multivesicular body biogenesis.
Coonrod EM, Stevens TH
Mol Biol Cell 2010 Dec;21(23):4057-60
Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum.
Ryan M, Graham LA, Stevens TH
Mol Biol Cell 2008 Dec;19(12):5131-42
Vma9p (subunit e) is an integral membrane V0 subunit of the yeast V-ATPase.
Compton MA, Graham LA, Stevens TH
J Biol Chem 2006 Jun 2;281(22):15312-9
Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body.
Lottridge JM, Flannery AR, Vincelli JL, Stevens TH
Proc Natl Acad Sci U S A 2006 Apr 18;103(16):6202-7
Topological characterization of the c, c', and c" subunits of the vacuolar ATPase from the yeast Saccharomyces cerevisiae.
Flannery AR, Graham LA, Stevens TH
J Biol Chem 2004 Sep 17;279(38):39856-62
Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p.
Conibear E, Cleck JN, Stevens TH
Mol Biol Cell 2003 Apr;14(4):1610-23
Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole.
Kweon Y, Rothe A, Conibear E, Stevens TH
Mol Biol Cell 2003 May;14(5):1868-81
Structure and assembly of the yeast V-ATPase.
Graham LA, Flannery AR, Stevens TH
J Bioenerg Biomembr 2003 Aug;35(4):301-12
Studying yeast vacuoles.
Conibear E, Stevens TH
Methods Enzymol 2002;351:408-32
Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae.
Sagermann M, Stevens TH, Matthews BW
Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7134-9
Composition and assembly of the yeast vacuolar H(+)-ATPase complex.
Graham LA, Powell B, Stevens TH
J Exp Biol 2000 Jan;203(Pt 1):61-70
Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi.
Conibear E, Stevens TH
Mol Biol Cell 2000 Jan;11(1):305-23
VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment.
Gerrard SR, Bryant NJ, Stevens TH
Mol Biol Cell 2000 Feb;11(2):613-26
Molecular characterization of the yeast vacuolar H+-ATPase proton pore.
Powell B, Graham LA, Stevens TH
J Biol Chem 2000 Aug 4;275(31):23654-60
The sodium/proton exchanger Nhx1p is required for endosomal protein trafficking in the yeast Saccharomyces cerevisiae.
Bowers K, Levi BP, Patel FI, Stevens TH
Mol Biol Cell 2000 Dec;11(12):4277-94
The yeast endosomal t-SNARE, Pep12p, functions in the absence of its transmembrane domain.
Gerrard SR, Mecklem AB, Stevens TH
Traffic 2000 Jan;1(1):45-55
Pep12p is a multifunctional yeast syntaxin that controls entry of biosynthetic, endocytic and retrograde traffic into the prevacuolar compartment.
Gerrard SR, Levi BP, Stevens TH
Traffic 2000 Mar;1(3):259-69
Assembly of the yeast vacuolar proton-translocating ATPase.
Graham LA, Stevens TH
J Bioenerg Biomembr 1999 Feb;31(1):39-47
The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole.
Fischer von Mollard G, Stevens TH
Mol Biol Cell 1999 Jun;10(6):1719-32
Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p.
Voos W, Stevens TH
J Cell Biol 1998 Feb 9;140(3):577-90
Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuole.
Bryant NJ, Stevens TH
Microbiol Mol Biol Rev 1998 Mar;62(1):230-47
Traffic into the prevacuolar/endosomal compartment of Saccharomyces cerevisiae: a VPS45-dependent intracellular route and a VPS45-independent, endocytic route.
Bryant NJ, Piper RC, Gerrard SR, Stevens TH
Eur J Cell Biol 1998 May;76(1):43-52
Assembly of the yeast vacuolar H+-ATPase occurs in the endoplasmic reticulum and requires a Vma12p/Vma22p assembly complex.
Graham LA, Hill KJ, Stevens TH
J Cell Biol 1998 Jul 13;142(1):39-49
Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment.
Bryant NJ, Piper RC, Weisman LS, Stevens TH
J Cell Biol 1998 Aug 10;142(3):651-63
Multiple sorting pathways between the late Golgi and the vacuole in yeast.
Conibear E, Stevens TH
Biochim Biophys Acta 1998 Aug 14;1404(1-2):211-30