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IMB Retreat 2008

Asymmetric cell division, in which fate determinants are segregated into distinct daughter cells, is a mechanism for generating cellular diversity used in organisms ranging from bacteria to mammals. In eukaryotes, asymmetric cell division requires that the mitotic spindle be aligned with the axis of cell polarity. This image depicts our current understanding of the molecular mechanism by which spindle orientation occurs in Drosophila neuroblasts, a model system for asymmetric cell division. Heterotrimeric G-proteins associated with the membrane bind Partner of Inscuteable (Pins) which links to the microtuble-binding protein Mushroom-body defect (Mud). Pins therefore acts as an adaptor that links signaling information to spindle orientation.

PNAS, v.104 (36), September 4, 2007
Prehoda Lab

Recent IMB Research Publications

Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch
Development 135(4):707-15.
Herman Lab

Direct Spectroscopic Study of Reconstituted Transcription Complexes Reveals That Intrinsic Termination Is Driven Primarily by Thermodynamic Destabilization of the Nucleic Acid Framework.
J. Biol. Chem. 283:3537-49
von Hippel Lab

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