IMB turns 50
We are celebrating our 50th birthday October 23-24 with a scientific symposium featuring some of our esteemed alumni. Additional information can be found at http://www.molbio.uoregon.edu/IMB50.
The Institute of Molecular Biology at the University of Oregon is an interdisciplinary research community, founded in 1959, dedicated to investigating biological questions at the molecular level. Our collaborative and interactive Institute brings together--from the Departments of Biology, Chemistry, and Physics -- scientists using diverse approaches and state-of-the-art facilities. This rich research environment provides exceptional training opportunities for young scientists.
Compositive image of adult mouse cerebellar folia duplicated, rotated, and reflected to generate two-dimensional symmetry. The cyclin-dependent kinase inhibitor and tumor suppressor p27kip1 (p27) is required for proper cell cycle exit timing in cerebellar granule cells. MADM, a genetic mosaic system, achieves p27 inactivation and simultaneous labeling in sporadic cells in mice, closely mimicking physiologic loss of heterozygosity. Mosaic knockout of p27 in granule cells results in drastic expansion of p27-/- cells (green) compared to p27+/+ cells (red) within the same animal. Zong Lab.
Recent IMB Research Publications
Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch Development 135(4):707-15. Herman Lab
Direct Spectroscopic Study of Reconstituted Transcription Complexes Reveals That Intrinsic Termination Is Driven Primarily by Thermodynamic Destabilization of the Nucleic Acid Framework. J. Biol. Chem. 283:3537-49 von Hippel Lab
297 Klamath Hall Hall